Author: Oh, Soo-Jin; Choi, Young-Ki; Shin, Ok Sarah
Title: Systems Biology-Based Platforms to Accelerate Research of Emerging Infectious Diseases Document date: 2018_3_1
ID: ta5y54lu_25
Snippet: In addition to transcriptome analysis, other systems-level approaches, such as proteomics, metabolomics, and lipidomics, can provide greater depth in evaluating correlates of vaccine-induced immunity. The latest research by Dr. Pulendran's group analyzed vaccine-induced immunity in multi-scale ways in different age groups of healthy adults immunized with shin-gles vaccine, Zostavax. 77 The authors presented an integration data of peripheral blood.....
Document: In addition to transcriptome analysis, other systems-level approaches, such as proteomics, metabolomics, and lipidomics, can provide greater depth in evaluating correlates of vaccine-induced immunity. The latest research by Dr. Pulendran's group analyzed vaccine-induced immunity in multi-scale ways in different age groups of healthy adults immunized with shin-gles vaccine, Zostavax. 77 The authors presented an integration data of peripheral blood mononuclear cells (PBMC) transcriptomics, flow cytometry of blood cell populations, plasma cytokine analysis, and metabolomics. The integration of these data revealed transcriptomic association with metabolic correlates of vaccine immunity. Interestingly, this analysis revealed sterol regulatory binding protein-1 and its targets as potentially key integrators of antibody and follicular helper T cell responses. Therefore, these data suggest that blood cells potentially regulate gene transcription in response to metabolic cues, suggesting the value in integration of diverse systems-level data.
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