Author: Roshan Kumar; Helianthous Verma; Nirjara Singhvi; Utkarsh Sood; Vipin Gupta; Mona Singh; Rashmi Sharma; Princy Hira; Shekhar Nagar; Chandni Talwar; Namita Nayyar; Shailly Anand; Charu Dogra Rawat; Mansi Verma; Ram Kishan Negi; Yogendra Singh; Rup Lal
Title: Comparative Genomic Analysis of Rapidly Evolving SARS CoV-2 Viruses Reveal Mosaic Pattern of Phylogeographical Distribution Document date: 2020_3_30
ID: eqwxkwqa_36
Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.25.006213 doi: bioRxiv preprint human promonocytes via MAPK pathway result in pro-fibrotic responses [59] . This reflects 316 that viral PL-PRO antagonises innate immune system and is directly involved in the 317 pathogenicity of SARS-CoV-2 induced pulmonary fibrosis [56, 58] . Many COVID-19 patients 318 develop acute respiratory distress.....
Document: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.25.006213 doi: bioRxiv preprint human promonocytes via MAPK pathway result in pro-fibrotic responses [59] . This reflects 316 that viral PL-PRO antagonises innate immune system and is directly involved in the 317 pathogenicity of SARS-CoV-2 induced pulmonary fibrosis [56, 58] . Many COVID-19 patients 318 develop acute respiratory distress syndrome (ADRS) which leads to pulmonary edema and 319 lung failure [60, 61] . These symptoms are because of cytokine storm manifesting elevated 320 levels of pro-inflammatory cytokines like IL6, IFNγ, IL17, IL1β etc [61] . These results are in 321 agreement with our prediction where we found IL6 as an interacting partner. Our study also 322 showed JAK1/2 as an interacting partner which is known for IFNγ signaling. It is well known 323 that TGFβ along with IL6 and STAT3 promotes Th17 differentiation by inhibiting SOCS3 324
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