Author: Peña, José; Chen-Harris, Haiyin; Allen, Jonathan E.; Hwang, Mona; Elsheikh, Maher; Mabery, Shalini; Bielefeldt-Ohmann, Helle; Zemla, Adam T.; Bowen, Richard A.; Borucki, Monica K.
Title: Sendai virus intra-host population dynamics and host immunocompetence influence viral virulence during in vivo passage Document date: 2016_4_9
ID: z7f720dj_2
Snippet: Serial passage of a virus in laboratory animals is often used to increase pathogenicity of the virus for that host in order to generate a laboratory model of the disease (Aronson, Herzog, and Jerrells 1995; Tiwari et al. 2006) . For example, passage of the SARS virus in rats generated a viral variant with a point mutation in the spike protein, and this mutation increased the efficiency of interaction of the spike protein and the viral receptor on.....
Document: Serial passage of a virus in laboratory animals is often used to increase pathogenicity of the virus for that host in order to generate a laboratory model of the disease (Aronson, Herzog, and Jerrells 1995; Tiwari et al. 2006) . For example, passage of the SARS virus in rats generated a viral variant with a point mutation in the spike protein, and this mutation increased the efficiency of interaction of the spike protein and the viral receptor on the rat cells (Nagata, et al. 2007 ). Interestingly, data from this same study showed that both host and viral factors are associated with increased virulence, as virulence was associated with increased age of the rodent as well as mutations in the viral genome.
Search related documents:
Co phrase search for related documents- increase age and spike protein: 1, 2, 3, 4, 5, 6
- increase virulence and SARS virus: 1, 2, 3
- increase virulence and serial passage: 1
- increase virulence and spike protein: 1
- laboratory animal and SARS virus: 1, 2, 3, 4
- laboratory animal and spike protein: 1, 2, 3, 4
- laboratory model and SARS virus: 1, 2, 3, 4, 5
- point mutation and SARS virus: 1, 2, 3, 4, 5, 6, 7, 8
- point mutation and spike protein: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- point mutation and spike protein point mutation: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13
- rat cell and SARS virus: 1
- SARS virus and serial passage: 1
- SARS virus and spike protein: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- SARS virus and spike protein point mutation: 1, 2
- serial passage and spike protein: 1, 2, 3, 4, 5
Co phrase search for related documents, hyperlinks ordered by date