Author: Peña, José; Chen-Harris, Haiyin; Allen, Jonathan E.; Hwang, Mona; Elsheikh, Maher; Mabery, Shalini; Bielefeldt-Ohmann, Helle; Zemla, Adam T.; Bowen, Richard A.; Borucki, Monica K.
Title: Sendai virus intra-host population dynamics and host immunocompetence influence viral virulence during in vivo passage Document date: 2016_4_9
ID: z7f720dj_59
Snippet: The third high-frequency variant present in the HN gene was detected at nt 8,265 and resulted in a K525Q non-synonymous consensus mutation for the same two guinea pig samples as E461K, samples ND.GP3 and SD.GP3. This A to C nt substitution was detected at 11% in the seed inoculum and ranged between 3 and 21% in the P1 samples, 16-41% in P10 samples, and 27-91% in the guinea pig samples. Thus it appears that all three mutations in the HN gene were.....
Document: The third high-frequency variant present in the HN gene was detected at nt 8,265 and resulted in a K525Q non-synonymous consensus mutation for the same two guinea pig samples as E461K, samples ND.GP3 and SD.GP3. This A to C nt substitution was detected at 11% in the seed inoculum and ranged between 3 and 21% in the P1 samples, 16-41% in P10 samples, and 27-91% in the guinea pig samples. Thus it appears that all three mutations in the HN gene were enriched during in vivo passage.
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