Author: Peña, José; Chen-Harris, Haiyin; Allen, Jonathan E.; Hwang, Mona; Elsheikh, Maher; Mabery, Shalini; Bielefeldt-Ohmann, Helle; Zemla, Adam T.; Bowen, Richard A.; Borucki, Monica K.
Title: Sendai virus intra-host population dynamics and host immunocompetence influence viral virulence during in vivo passage Document date: 2016_4_9
ID: z7f720dj_76
Snippet: HN plays a critical role in mediating the virus entry into the host cell thus structural modeling was used to assess the potential impact of the mutations on the viral phenotype. HN glycoproteins initiate virus-cell fusion by binding to the sialic acids found on the surface of the host cell (hemagglutinin activity), trigger a structural refolding of a trimeric fusion protein F needed for merging of viral and cell membranes, and facilitate viral a.....
Document: HN plays a critical role in mediating the virus entry into the host cell thus structural modeling was used to assess the potential impact of the mutations on the viral phenotype. HN glycoproteins initiate virus-cell fusion by binding to the sialic acids found on the surface of the host cell (hemagglutinin activity), trigger a structural refolding of a trimeric fusion protein F needed for merging of viral and cell membranes, and facilitate viral assembly and budding by cleaving the glycosidic linkages with sialic acids via neuraminidase activity. The ectodomain part of the HN proteins is composed of a helical stalk with a large globular head, and the functional form of the molecule (biological assembly) is a tetramer.
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