Author: Longxian Lv; Gaolei Li; Jinhui Chen; Xinle Liang; Yudong Li
Title: Comparative genomic analysis revealed specific mutation pattern between human coronavirus SARS-CoV-2 and Bat-SARSr-CoV RaTG13 Document date: 2020_3_2
ID: 3h1o0oz3_14
Snippet: To investigate the potential relative synonymous codon usage (RSCU) bias of the spike protein from SARS-CoV-2 and its closely related coronaviruses, the coding sequence (CDS) of spike protein in these coronaviruses were calculated with CodonW 1.4.4 (http://codonw.sourceforge.net/). The RSCU of human genes was retrieved from the Codon Usage Database (http://www.kazusa.or.jp/codon/). The potential relationships among these sequences were calculated.....
Document: To investigate the potential relative synonymous codon usage (RSCU) bias of the spike protein from SARS-CoV-2 and its closely related coronaviruses, the coding sequence (CDS) of spike protein in these coronaviruses were calculated with CodonW 1.4.4 (http://codonw.sourceforge.net/). The RSCU of human genes was retrieved from the Codon Usage Database (http://www.kazusa.or.jp/codon/). The potential relationships among these sequences were calculated with a squared Euclidean distance ( u h u ). Besides RSCU, the effective number of codons (ENc) was used as a simple metrics to verify codon bias and to explore the source of virus.
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