Author: Jeang, Kuan-Teh; Yedavalli, Venkat
Title: Role of RNA helicases in HIV-1 replication Document date: 2006_8_25
ID: vefs1h6o_22
Snippet: We are in the preliminary stages of screening ringexpanded nucleoside analogs found previously to be successful NTPase/helicase inhibitors of West Nile virus, Hepatitis C virus and Japanese encephalitis virus (81, 82) . We have observed that a few of these candidate inhibitors have substantial anti-HIV-1 activity at doses that do not incur cytotoxicity to cells treated in tissue culture for 1 week. Further studies are needed before concluding tha.....
Document: We are in the preliminary stages of screening ringexpanded nucleoside analogs found previously to be successful NTPase/helicase inhibitors of West Nile virus, Hepatitis C virus and Japanese encephalitis virus (81, 82) . We have observed that a few of these candidate inhibitors have substantial anti-HIV-1 activity at doses that do not incur cytotoxicity to cells treated in tissue culture for 1 week. Further studies are needed before concluding that these compounds exert specific inhibition of DDX3, one of the other cellular helicases, or some other target altogether.
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