Author: Kerr, William G; Park, Mi-Young; Maubert, Monique; Engelman, Robert W
Title: SHIP deficiency causes Crohn's disease-like ileitis Document date: 2010_10_12
ID: qde4so1x_5
Snippet: < Despite enhanced immune regulation in the peripheral lymphoid tissues of SHIP-deficient mice, immune function and regulation is compromised in the small intestine of these mice. < Normal immune function and homeostasis in the small intestine requires enzymatically active SHIP. < Expression of SHIP by intestinal epithelial cells is not required for the integrity of the small intestine. < SHIP-deficient haematolymphoid cells are sufficient to tra.....
Document: < Despite enhanced immune regulation in the peripheral lymphoid tissues of SHIP-deficient mice, immune function and regulation is compromised in the small intestine of these mice. < Normal immune function and homeostasis in the small intestine requires enzymatically active SHIP. < Expression of SHIP by intestinal epithelial cells is not required for the integrity of the small intestine. < SHIP-deficient haematolymphoid cells are sufficient to transfer ileitis to wild-type hosts. < There is a paucity of both CD4 and CD8 T cells in the small intestine of SHIP-deficient mice. < There is local neutrophilia in the small intestines of SHIP-deficient mice.
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