Author: Kenworthy, Rachael; Lambert, Diana; Yang, Feng; Wang, Nan; Chen, Zihong; Zhu, Haizhen; Zhu, Fanxiu; Liu, Chen; Li, Kui; Tang, Hengli
Title: Short-hairpin RNAs delivered by lentiviral vector transduction trigger RIG-I-mediated IFN activation Document date: 2009_9_3
ID: uvf5qzfd_1
Snippet: A specific double-stranded RNA (dsRNA) structure, $21-22 bp dsRNA with 3 0 overhangs, plays a critical role in initiating both microRNA (miRNA)-and small interfering RNA (siRNA)-mediated gene silencing, as it is the structure recognized by the RNA interference (RNAi) machinery, the RNA-induced silencing complex (RISC) (1) (2) (3) . Except for preformed siRNA duplexes of $21 bp, the RISC-loaded small RNAs are generated by a ribonuclease (RNase) II.....
Document: A specific double-stranded RNA (dsRNA) structure, $21-22 bp dsRNA with 3 0 overhangs, plays a critical role in initiating both microRNA (miRNA)-and small interfering RNA (siRNA)-mediated gene silencing, as it is the structure recognized by the RNA interference (RNAi) machinery, the RNA-induced silencing complex (RISC) (1) (2) (3) . Except for preformed siRNA duplexes of $21 bp, the RISC-loaded small RNAs are generated by a ribonuclease (RNase) III-like enzyme that is found in virtually all eukaryotic organisms. This enzyme, aptly named Dicer for its ability to cleave a variety of larger (>30 bp) dsRNA molecules into the $21 bp dsRNA with a characteristic 3 0 overhang of 2 nt, is a multidomain RNA-binding protein and itself a component of RISC.
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