Selected article for: "antiviral effect and gene expression"
Author: Kenworthy, Rachael; Lambert, Diana; Yang, Feng; Wang, Nan; Chen, Zihong; Zhu, Haizhen; Zhu, Fanxiu; Liu, Chen; Li, Kui; Tang, Hengli
Title: Short-hairpin RNAs delivered by lentiviral vector transduction trigger RIG-I-mediated IFN activation
  • Document date: 2009_9_3
    • ID: uvf5qzfd_3
    Snippet: dsRNAs are also a type of pathogen-associated molecular pattern (PAMP) that are detected by cellular innate immunity sensors named Pattern Recognition Receptors (PRRs) (4) . The interaction between a PAMP and a PRR triggers activation of the interferon (IFN) pathway in mammalian cells, which significantly changes the gene-expression profile in the cells and contributes to the well-documented off-target effect of RNAi. IFN induction is especially .....
    Document: dsRNAs are also a type of pathogen-associated molecular pattern (PAMP) that are detected by cellular innate immunity sensors named Pattern Recognition Receptors (PRRs) (4) . The interaction between a PAMP and a PRR triggers activation of the interferon (IFN) pathway in mammalian cells, which significantly changes the gene-expression profile in the cells and contributes to the well-documented off-target effect of RNAi. IFN induction is especially problematic in antiviral studies employing RNAi, where the antiviral effect of IFN must be distinguished from that of RNAi.

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