Selected article for: "increase IRES activity and ires activity"
Author: Gendron, Karine; Ferbeyre, Gerardo; Heveker, Nikolaus; Brakier-Gingras, Léa
Title: The activity of the HIV-1 IRES is stimulated by oxidative stress and controlled by a negative regulatory element
  • Document date: 2010_10_8
    • ID: qtn3ukf4_33
    Snippet: It could be argued that the effect of mutating IRENE or inducing oxidative stress is modest. It is however worth recalling that an increase of $2-fold in the IRES activity of the foot-and-mouth disease virus was related to its hypervirulence in BHK (baby hamster kidney) À21 cells (56) and that an increase of $2-fold in the IRES activity of c-myc-RNA was linked to the occurrence of multiple myeloma (57) . Also, microRNAs have powerful physiologic.....
    Document: It could be argued that the effect of mutating IRENE or inducing oxidative stress is modest. It is however worth recalling that an increase of $2-fold in the IRES activity of the foot-and-mouth disease virus was related to its hypervirulence in BHK (baby hamster kidney) À21 cells (56) and that an increase of $2-fold in the IRES activity of c-myc-RNA was linked to the occurrence of multiple myeloma (57) . Also, microRNAs have powerful physiological effects although their effects on translation of individual targets are often moderate, being in the range of 1.5-2-fold (58, 59) .

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