Author: Liu, Yuan-yuan; Chen, Liang-jun; Zhong, Yan; Shen, Meng-xin; Ma, Nian; Liu, Bing-yu; Luo, Fan; Hou, Wei; Yang, Zhan-qiu; Xiong, Hai-rong
Title: Specific interference shRNA-expressing plasmids inhibit Hantaan virus infection in vitro and in vivo Document date: 2016_3_14
ID: pwlybr2h_32
Snippet: We further detected reductions of viral antigen expression in the HTNV-infected Vero-E6 cells treated with 2 μg plasmid throughout the course of a 9-d infection. The greatest inhibitory rates were noted at 3 dpi (76.1%±1.3% for pSilencer-S and 78.2%±2.4% for pSilencer-M, Figure 2J) . Moreover, the antiviral effect lasted at least 7 d (43.5%±3.4% for pSilencer-S and 46.7%±3.2% for pSilencer-M at 7 dpi)......
Document: We further detected reductions of viral antigen expression in the HTNV-infected Vero-E6 cells treated with 2 μg plasmid throughout the course of a 9-d infection. The greatest inhibitory rates were noted at 3 dpi (76.1%±1.3% for pSilencer-S and 78.2%±2.4% for pSilencer-M, Figure 2J) . Moreover, the antiviral effect lasted at least 7 d (43.5%±3.4% for pSilencer-S and 46.7%±3.2% for pSilencer-M at 7 dpi).
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