Author: Chang, Stewart T.; Thomas, Matthew J.; Sova, Pavel; Green, Richard R.; Palermo, Robert E.; Katze, Michael G.
Title: Next-Generation Sequencing of Small RNAs from HIV-Infected Cells Identifies Phased microRNA Expression Patterns and Candidate Novel microRNAs Differentially Expressed upon Infection Document date: 2013_2_5
ID: t98g8z7i_11
Snippet: To determine the possible effects of HIVinduced changes in microRNA expression, we performed a correlative analysis with mRNA expression data. We obtained predictions of microRNA complementarity to 3= untranslated regions (UTRs) in mRNAs from various algorithms and then compared expression profiles from small RNA-Seq and mRNA-Seq from the same samples (1). MicroRNAs and possible target mRNAs having significant, negative correlations (anticorrelat.....
Document: To determine the possible effects of HIVinduced changes in microRNA expression, we performed a correlative analysis with mRNA expression data. We obtained predictions of microRNA complementarity to 3= untranslated regions (UTRs) in mRNAs from various algorithms and then compared expression profiles from small RNA-Seq and mRNA-Seq from the same samples (1). MicroRNAs and possible target mRNAs having significant, negative correlations (anticorrelations) were identified, and the annotations of the anticorrelated target mRNAs were used to determine possible functional effects of the microRNAs.
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