Author: Chang, Stewart T.; Sova, Pavel; Peng, Xinxia; Weiss, Jeffrey; Law, G. Lynn; Palermo, Robert E.; Katze, Michael G.
Title: Next-Generation Sequencing Reveals HIV-1-Mediated Suppression of T Cell Activation and RNA Processing and Regulation of Noncoding RNA Expression in a CD4(+) T Cell Line Document date: 2011_9_20
ID: zyzgk2z3_1
Snippet: T he hallmark of AIDS is the loss of CD4 Ï© T cells, the primary target of human immunodeficiency virus type 1 (HIV-1) infection. Infected CD4 Ï© T cells undergo fundamental changes that eventually result in cell death and the release of new virus particles (reviewed in references 1 and 2). Following the uptake of virus, the viral genome is reverse transcribed and integrated into the host genome. The host machinery is then used to produce viral t.....
Document: T he hallmark of AIDS is the loss of CD4 Ï© T cells, the primary target of human immunodeficiency virus type 1 (HIV-1) infection. Infected CD4 Ï© T cells undergo fundamental changes that eventually result in cell death and the release of new virus particles (reviewed in references 1 and 2). Following the uptake of virus, the viral genome is reverse transcribed and integrated into the host genome. The host machinery is then used to produce viral transcripts that are either spliced into smaller transcripts that serve as the template for viral proteins or left unspliced to be incorporated into new virus particles. Microarray analyses have shown that infected cells respond to these assaults with gene expression changes in a number of pathways, including apoptosis, cell cycle, cholesterol biosynthesis, and inflammation (3) (4) (5) ; reference 1 and references therein).
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