Author: Peña, José; Chen-Harris, Haiyin; Allen, Jonathan E.; Hwang, Mona; Elsheikh, Maher; Mabery, Shalini; Bielefeldt-Ohmann, Helle; Zemla, Adam T.; Bowen, Richard A.; Borucki, Monica K.
Title: Sendai virus intra-host population dynamics and host immunocompetence influence viral virulence during in vivo passage Document date: 2016_4_9
ID: z7f720dj_31
Snippet: Sequence variability/conservation scores were calculated from amino acids frequencies per positions in sequence and structure-based alignments using Sum-of-Pairs algorithm with BLOSUM62 as an amino acids substitution matrix. Structure variability/conservation analysis was performed by StralSV (Zemla et al. 2011 ) applied to all sixty-one currently available variants (PDB chains) of structural models of paramyxovirus HNs deposited in PDB (date: 4 .....
Document: Sequence variability/conservation scores were calculated from amino acids frequencies per positions in sequence and structure-based alignments using Sum-of-Pairs algorithm with BLOSUM62 as an amino acids substitution matrix. Structure variability/conservation analysis was performed by StralSV (Zemla et al. 2011 ) applied to all sixty-one currently available variants (PDB chains) of structural models of paramyxovirus HNs deposited in PDB (date: 4 August 2015). Conserved sialic acid binding site residues were identified based on results published by Connaris et al. (2002) and from alignments calculated between HN proteins.
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