Selected article for: "frameshift stem loop and local stability"
Author: Yu, Chien-Hung; Noteborn, Mathieu H.; Pleij, Cornelis W. A.; Olsthoorn, René C. L.
Title: Stem–loop structures can effectively substitute for an RNA pseudoknot in -1 ribosomal frameshifting
  • Document date: 2011_7_29
    • ID: wifs97yy_35
    Snippet: In conclusion, our data show that hairpins of various base composition in stem and loop can act as efficient frameshift stimulators. Combined with previous studies on antisense-induced frameshifting (43, 44) , these data support the notion that downstream structures primarily serve as barriers to stall translating ribosomes to stimulate frameshifting. Although there exists a linear relationship between calculated stability and frameshifting, loca.....
    Document: In conclusion, our data show that hairpins of various base composition in stem and loop can act as efficient frameshift stimulators. Combined with previous studies on antisense-induced frameshifting (43, 44) , these data support the notion that downstream structures primarily serve as barriers to stall translating ribosomes to stimulate frameshifting. Although there exists a linear relationship between calculated stability and frameshifting, local destabilizing elements like bulges or mismatches in a hairpin can greatly influence frameshift-inducing activity. Future experiments addressing the mechanical strength of these hairpins (7-9) may help to improve our understanding of the basics of ribosomal frameshifting.

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