Author: Xie, Xin-Hui; Wang, Xin-Luan; Yang, Hui-Lin; Zhao, De-Wei; Qin, Ling
Title: Steroid-associated osteonecrosis: Epidemiology, pathophysiology, animal model, prevention, and potential treatments (an overview) Document date: 2015_1_13
ID: y6y235hw_16
Snippet: The pathophysiology of SAON remains controversial and different mechanisms including the abnormality of the bone marrow stem cell (BMSC) pool, hyperlipidemia, fat emboli, hypercoagulable condition, vascular endothelial dysfunction, and apoptosis of bone tissues have been proposed extensively. SAON is not caused by only one factor but multiple factors and these influence each other during the process of SAON development (Fig. 2) , which subsequent.....
Document: The pathophysiology of SAON remains controversial and different mechanisms including the abnormality of the bone marrow stem cell (BMSC) pool, hyperlipidemia, fat emboli, hypercoagulable condition, vascular endothelial dysfunction, and apoptosis of bone tissues have been proposed extensively. SAON is not caused by only one factor but multiple factors and these influence each other during the process of SAON development (Fig. 2) , which subsequently results in marrow ischaemia and eventually ON.
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