Selected article for: "Bat cov and Human SARS"
Author: Longxian Lv; Gaolei Li; Jinhui Chen; Xinle Liang; Yudong Li
Title: Comparative genomic analysis revealed specific mutation pattern between human coronavirus SARS-CoV-2 and Bat-SARSr-CoV RaTG13
  • Document date: 2020_3_2
    • ID: 3h1o0oz3_25
    Snippet: To investigate whether the mutation pattern between SARS-CoV-2 and RaTG13 is unique across all coronavirus species, we further compared their alterations of nucleotides and amino acids in comparison to other representative coronaviruses. Phylogenetic analysis of SARS-CoV-2 and its 20 closely related coronaviruses formed four well supported clades (Fig. 2) . The two SARS-CoV-2 strain WIV04 (from Wuhan) and SNU01 (from Korea patient) were clustered.....
    Document: To investigate whether the mutation pattern between SARS-CoV-2 and RaTG13 is unique across all coronavirus species, we further compared their alterations of nucleotides and amino acids in comparison to other representative coronaviruses. Phylogenetic analysis of SARS-CoV-2 and its 20 closely related coronaviruses formed four well supported clades (Fig. 2) . The two SARS-CoV-2 strain WIV04 (from Wuhan) and SNU01 (from Korea patient) were clustered with SARS-CoV-related strains to form clade 1, belonging to beta-coronavirus lineage B. The Compared with Bat-SARSr-CoV RaTG13, there were 293 nucleotideswere altered while only 29 amino acids were altered in SARS-CoV-2; their ratio was as high as 9.07. However, this ratio detected in the comparisons of other human coronaviruses with their similar animal coronaviruses was less than 5.0. For example, the ratio of human SARS-CoV Tor2 to bat SARS-like CoVs LYRa11 was 4.81; that ratio of human MERS-CoV EMC2012 to bat SARS-like CoVs RSA2011 was 2.80; that ratio of human coronavirus 229E to bat coronavirus HKU2 was 4.55. These results indicate that the relative level of synonymous substitutions between human SARS-CoV-2 and its possible animal origin (RaTG13) is much higher than that between other human coronaviruses and their potential animal sources.

    Search related documents:
    Co phrase search for related documents
    • amino acid and animal source: 1, 2, 3, 4, 5, 6, 7, 8, 9
    • amino acid and Bat SARSr cov: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16
    • amino acid and beta coronavirus: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13
    • amino acid and beta coronavirus lineage: 1, 2
    • amino acid and mer cov: 1, 2, 3
    • amino acid and mutation pattern: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12
    • amino acid and phylogenetic analysis: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • amino acid and potential animal source: 1
    • amino acid nucleotide and Bat SARSr cov: 1, 2, 3
    • amino acid nucleotide and beta coronavirus: 1
    • amino acid nucleotide and beta coronavirus lineage: 1
    • amino acid nucleotide and mutation pattern: 1, 2
    • amino acid nucleotide and phylogenetic analysis: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • animal origin and Bat SARSr cov: 1, 2
    • animal origin and phylogenetic analysis: 1, 2, 3, 4, 5, 6, 7, 8
    • animal origin and possible animal origin: 1, 2, 3
    • animal origin and potential animal source: 1
    • animal source and phylogenetic analysis: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
    • animal source and potential animal source: 1, 2, 3, 4, 5, 6, 7, 8