Author: Longxian Lv; Gaolei Li; Jinhui Chen; Xinle Liang; Yudong Li
Title: Comparative genomic analysis revealed specific mutation pattern between human coronavirus SARS-CoV-2 and Bat-SARSr-CoV RaTG13 Document date: 2020_3_2
ID: 3h1o0oz3_25
Snippet: To investigate whether the mutation pattern between SARS-CoV-2 and RaTG13 is unique across all coronavirus species, we further compared their alterations of nucleotides and amino acids in comparison to other representative coronaviruses. Phylogenetic analysis of SARS-CoV-2 and its 20 closely related coronaviruses formed four well supported clades (Fig. 2) . The two SARS-CoV-2 strain WIV04 (from Wuhan) and SNU01 (from Korea patient) were clustered.....
Document: To investigate whether the mutation pattern between SARS-CoV-2 and RaTG13 is unique across all coronavirus species, we further compared their alterations of nucleotides and amino acids in comparison to other representative coronaviruses. Phylogenetic analysis of SARS-CoV-2 and its 20 closely related coronaviruses formed four well supported clades (Fig. 2) . The two SARS-CoV-2 strain WIV04 (from Wuhan) and SNU01 (from Korea patient) were clustered with SARS-CoV-related strains to form clade 1, belonging to beta-coronavirus lineage B. The Compared with Bat-SARSr-CoV RaTG13, there were 293 nucleotideswere altered while only 29 amino acids were altered in SARS-CoV-2; their ratio was as high as 9.07. However, this ratio detected in the comparisons of other human coronaviruses with their similar animal coronaviruses was less than 5.0. For example, the ratio of human SARS-CoV Tor2 to bat SARS-like CoVs LYRa11 was 4.81; that ratio of human MERS-CoV EMC2012 to bat SARS-like CoVs RSA2011 was 2.80; that ratio of human coronavirus 229E to bat coronavirus HKU2 was 4.55. These results indicate that the relative level of synonymous substitutions between human SARS-CoV-2 and its possible animal origin (RaTG13) is much higher than that between other human coronaviruses and their potential animal sources.
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