Author: Willemsen, Anouk; Zwart, Mark P
Title: On the stability of sequences inserted into viral genomes Document date: 2019_11_14
ID: vv5gpldi_20
Snippet: In summary, engineered dsDNA viruses containing foreign gene insertions are relatively unstable and stability is only reached when the genomic context and demographic conditions (e.g. census population sizes, bottleneck sizes, and population structure) are optimal. Contrarily, in natural conditions dsDNA viruses appear to be highly plastic where increases and decreases in genome size occur on a relatively short evolutionary time scale. In particu.....
Document: In summary, engineered dsDNA viruses containing foreign gene insertions are relatively unstable and stability is only reached when the genomic context and demographic conditions (e.g. census population sizes, bottleneck sizes, and population structure) are optimal. Contrarily, in natural conditions dsDNA viruses appear to be highly plastic where increases and decreases in genome size occur on a relatively short evolutionary time scale. In particular, host-switches may play important roles in increased plasticity and stability of dsDNA viral genomes. Even though unstable viral genomes may help increase viral fitness by avoiding the hosts' immune system in natural conditions, it may also prevent the development of stable viral expression vectors in bioreactor configurations.
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