RESEARCH COMMUNICATIONS OF THE 28th ECVIM-CA CONGRESS

Serum sRAGE concentrations ranged from 52–3,260 ng/L (median: 287 ng/L) in all CIE dogs, with 65 dogs (64%) having a serum sRAGE concentration ≤340 ng/L (cut‐off previously best separating CIE dogs from healthy controls). Serum sRAGE levels were not associated with the severity of clinical signs (CCECAI scores), serum CRP, serum and fecal calprotectin, and fecal S100A12 concentrations (all P>0.05). Serum sRAGE and S100A12 concentrations tended to be inversely correlated, but statistical significance for this association was not reached (P=0.095). The overall histologic score was not associated with serum sRAGE levels (P=0.157), but microscopic lesions in the duodenum were more severe in dogs with serum sRAGE levels ≤340 ng/L (P=0.013). Serum sRAGE was significantly and inversely correlated with the severity of lymphoplasmacytic infiltration in the gastric antrum (P=0.038) and duodenum (P=0.017), and with crypt dilation (P=0.027) and the neutrophilic infiltrate in the duodenum (P=0.044).