Author: Peña, José; Chen-Harris, Haiyin; Allen, Jonathan E.; Hwang, Mona; Elsheikh, Maher; Mabery, Shalini; Bielefeldt-Ohmann, Helle; Zemla, Adam T.; Bowen, Richard A.; Borucki, Monica K.
Title: Sendai virus intra-host population dynamics and host immunocompetence influence viral virulence during in vivo passage Document date: 2016_4_9
ID: z7f720dj_82
Snippet: The high mutation rate of RNA viruses increases their ability to adapt to diverse hosts and cause novel human and veterinary diseases. It is likely that humans and animals swap viruses on a regular basis, with the vast majority of these transmission events going undetected. When these host jumps are detected it is hard to predict the likelihood that this new virus is capable of causing significant disease in the human population. Deep sequencing .....
Document: The high mutation rate of RNA viruses increases their ability to adapt to diverse hosts and cause novel human and veterinary diseases. It is likely that humans and animals swap viruses on a regular basis, with the vast majority of these transmission events going undetected. When these host jumps are detected it is hard to predict the likelihood that this new virus is capable of causing significant disease in the human population. Deep sequencing of viral populations provides important genetic information at a high level of resolution (Wanget al. 2007; Fishman and Branch 2009; Borucki et al. 2013; Morelli, et al. 2013; Andersen, et al. 2015) thus allowing detection of subconsensus mutations that may influence the infection outcome.
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