Author: Kenworthy, Rachael; Lambert, Diana; Yang, Feng; Wang, Nan; Chen, Zihong; Zhu, Haizhen; Zhu, Fanxiu; Liu, Chen; Li, Kui; Tang, Hengli
Title: Short-hairpin RNAs delivered by lentiviral vector transduction trigger RIG-I-mediated IFN activation Document date: 2009_9_3
ID: uvf5qzfd_40
Snippet: Interestingly, the loop A mutant, which contains a predicted loop of 7 nt, generated a siRNA duplex inside the cells that is slightly smaller than that of the shRNAs with a wild-type hairpin loop, suggesting the processing by Dicer into the stem, perhaps fulfilling the requirement of a length of 9 nt for the hairpin loop (46) . This mutant form of sh-B971 was not, however, able to trigger IFN activation......
Document: Interestingly, the loop A mutant, which contains a predicted loop of 7 nt, generated a siRNA duplex inside the cells that is slightly smaller than that of the shRNAs with a wild-type hairpin loop, suggesting the processing by Dicer into the stem, perhaps fulfilling the requirement of a length of 9 nt for the hairpin loop (46) . This mutant form of sh-B971 was not, however, able to trigger IFN activation.
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