Author: Blank, Maximilian F.; Chen, Sifan; Poetz, Fabian; Schnölzer, Martina; Voit, Renate; Grummt, Ingrid
Title: SIRT7-dependent deacetylation of CDK9 activates RNA polymerase II transcription Document date: 2017_3_17
ID: qm9urt2w_53
Snippet: Although SIRT7 does not harbor a classical RNA binding domain, the N-terminal region mediates the association of SIRT7 with RNA, and binding to RNA is required for the interaction of SIRT7 with numerous proteins. Other proteins, however, such as UBF and p53, associate with SIRT7 in an RNA-independent fashion, presumably via the C-terminal domain. These results are supported by previous studies showing that N-and C-terminal regions flanking the ca.....
Document: Although SIRT7 does not harbor a classical RNA binding domain, the N-terminal region mediates the association of SIRT7 with RNA, and binding to RNA is required for the interaction of SIRT7 with numerous proteins. Other proteins, however, such as UBF and p53, associate with SIRT7 in an RNA-independent fashion, presumably via the C-terminal domain. These results are supported by previous studies showing that N-and C-terminal regions flanking the catalytic domain enhance the activity of SIRT7 (36) and mediate interactions of SIRT7 with Mybbp1a, which inhibits the deacetylase activity of SIRT7 (37, 38) .
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