Author: Jasenosky, Luke D.; Cadena, Cristhian; Mire, Chad E.; Borisevich, Viktoriya; Haridas, Viraga; Ranjbar, Shahin; Nambu, Aya; Bavari, Sina; Soloveva, Veronica; Sadukhan, Supriya; Cassell, Gail H.; Geisbert, Thomas W.; Hur, Sun; Goldfeld, Anne E.
Title: The FDA-Approved Oral Drug Nitazoxanide Amplifies Host Antiviral Responses and Inhibits Ebola Virus Document date: 2019_8_8
ID: yomg30hg_21
Snippet: in NTZ's anti-EBOV activity in CRISPR/PKR-KD A549 cells by 72 h post-infection when compared with the CRISPR/Control A549 cells, indicating that PKR activity plays a critical role in NTZ's efficacy against EBOV. RIG-I depletion also resulted in an appreciable, although lesser, reduction in EBOV sensitivity to NTZ (2.7-fold) by 72 h post-infection ( Figure 4B ). By contrast, GADD34 depletion had little effect on NTZ's ability to inhibit EBOV growt.....
Document: in NTZ's anti-EBOV activity in CRISPR/PKR-KD A549 cells by 72 h post-infection when compared with the CRISPR/Control A549 cells, indicating that PKR activity plays a critical role in NTZ's efficacy against EBOV. RIG-I depletion also resulted in an appreciable, although lesser, reduction in EBOV sensitivity to NTZ (2.7-fold) by 72 h post-infection ( Figure 4B ). By contrast, GADD34 depletion had little effect on NTZ's ability to inhibit EBOV growth ( Figure 4B ).
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