Author: Liu, Yuan-yuan; Chen, Liang-jun; Zhong, Yan; Shen, Meng-xin; Ma, Nian; Liu, Bing-yu; Luo, Fan; Hou, Wei; Yang, Zhan-qiu; Xiong, Hai-rong
Title: Specific interference shRNA-expressing plasmids inhibit Hantaan virus infection in vitro and in vivo Document date: 2016_3_14
ID: pwlybr2h_4
Snippet: In the present study, we examined the effects of shRNAs on HTNV replication using 4 shRNAs that targeted different regions of the HTNV genomic RNA. We further transfected the two most effective shRNAs into the shRNA Expression Vector, pSilencer-3.0-H1 and named the resultant vectors pSilencer-S and pSilencer-M. The antiviral effect of pSilencer-S/M against HTNV was ultimately evaluated in tissue culture and a mouse model......
Document: In the present study, we examined the effects of shRNAs on HTNV replication using 4 shRNAs that targeted different regions of the HTNV genomic RNA. We further transfected the two most effective shRNAs into the shRNA Expression Vector, pSilencer-3.0-H1 and named the resultant vectors pSilencer-S and pSilencer-M. The antiviral effect of pSilencer-S/M against HTNV was ultimately evaluated in tissue culture and a mouse model.
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