Steroid-associated osteonecrosis animal model in rats

Zheng, Li-Zhen; Wang, Jia-Li; Kong, Ling; Huang, Le; Tian, Li; Pang, Qian-Qian; Wang, Xin-Luan; Qin, Ling

The body weight of SAON group rats were significantly lower 3 days after SAON induction (p < 0.05 compared between time points) and after which it was lower than that of the normal group rats (p < 0.05 compared between Figure 4 (A) The body weight of the SAON group rats were significantly lower 3 days after SAON induction (#: p < 0.05 compared between time points) and after that lower than that of the normal group rats (*: p < 0.05 compared between groups). (B) Animal dual energy X-ray absorptiometry (DXA) analysis on an oval-shaped region with a size of 0.8e1.0 cm 2 adjacent to the lateral tibia but not including any bone tissue (yellow oval); (C) results showed that there was no significant difference between the SAON group and normal group for fat percent at week 2, whereas at week 6, the fat percent of the SAON group was significantly higher; (D) results showed that there was no significant difference between the SAON group and normal group for lean mass at week 2, whereas at week 6, the lean mass of the SAON group was significantly lower (**: p < 0.01, n Z 6). SAON Z steroid-associated osteonecrosis. groups). DXA analysis showed that there was no significant difference between the SAON group and normal group for both percentage fat and lean mass at week 2; whereas at week 6, the percentage fat of SAON group was significantly higher, and the lean mass of SAON group was significantly lower (p < 0.01, n Z 6) (Fig. 4) .