Author: Xie, Xin-Hui; Wang, Xin-Luan; Yang, Hui-Lin; Zhao, De-Wei; Qin, Ling
Title: Steroid-associated osteonecrosis: Epidemiology, pathophysiology, animal model, prevention, and potential treatments (an overview) Document date: 2015_1_13
ID: y6y235hw_36
Snippet: To examine the mechanism or to identify the prevention and treatment efficiency of the biomaterial or pharmacological therapy strategies for SAON, different animal models (Table 1) were built up, including rabbit [8,10,11,35e37] , rat [38] , mouse [39, 40] , pig [41] , bipedal chicken [42] , and emu [22] . Among all experimental models, quadrupedal rabbits are commonly used for establishing SAON, which was proven to be a good animal model for dev.....
Document: To examine the mechanism or to identify the prevention and treatment efficiency of the biomaterial or pharmacological therapy strategies for SAON, different animal models (Table 1) were built up, including rabbit [8,10,11,35e37] , rat [38] , mouse [39, 40] , pig [41] , bipedal chicken [42] , and emu [22] . Among all experimental models, quadrupedal rabbits are commonly used for establishing SAON, which was proven to be a good animal model for developing high ON incidence in our recent work [7, 10, 11, 43, 44] and also by others [8, 35, 36] , yet without being able to develop to joint collapse, mainly explained by lower mechanical loading onto the weight-bearing joints.
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