Author: Xie, Xin-Hui; Wang, Xin-Luan; Yang, Hui-Lin; Zhao, De-Wei; Qin, Ling
Title: Steroid-associated osteonecrosis: Epidemiology, pathophysiology, animal model, prevention, and potential treatments (an overview) Document date: 2015_1_13
ID: y6y235hw_8
Snippet: Of all the nontraumatic factors, corticosteroid usage is the major associated one [5] . ON development was associated with dose and duration of administrating corticosteroids [6] . Usually, the chronic administration of high-dose steroids will result in ON, but it is very difficult to predict which patient under steroid administration will finally develop ON. Dynamic magnetic resonance imaging (MRI) was a promising method for potentially better p.....
Document: Of all the nontraumatic factors, corticosteroid usage is the major associated one [5] . ON development was associated with dose and duration of administrating corticosteroids [6] . Usually, the chronic administration of high-dose steroids will result in ON, but it is very difficult to predict which patient under steroid administration will finally develop ON. Dynamic magnetic resonance imaging (MRI) was a promising method for potentially better prediction in an SAON rabbit model [7] and human trials shall be conducted to confirm the value of SAON development already in Phase 0. A retrospective study showed that the interval between steroid administration and the ON onset was from 6 months to > 3 years. The prospective study using MRI to detect early ON of the femoral head showed that the initial changes of necrosis were found at about 3 months after administration of steroids.
Search related documents:
Co phrase search for related documents- high dose steroid and magnetic resonance imaging: 1
- human trial and initial change: 1
- human trial and magnetic resonance: 1
- human trial and magnetic resonance imaging: 1
- human trial and prospective study: 1
- initial change and prospective study: 1, 2
- initial change and retrospective study: 1, 2, 3, 4, 5
- MRI magnetic resonance imaging and promising method: 1
- MRI magnetic resonance imaging and prospective study: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23
- MRI magnetic resonance imaging and rabbit model: 1, 2, 3
- MRI magnetic resonance imaging and retrospective study: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30
- MRI magnetic resonance imaging and steroid administration: 1, 2
- promising method and prospective study: 1, 2, 3, 4, 5, 6
- prospective study and rabbit model: 1
- prospective study and retrospective study: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74
- prospective study and steroid administration: 1, 2
- rabbit model and SAON rabbit model: 1, 2, 3, 4
- retrospective study and steroid administration: 1
- SAON development and steroid administration: 1, 2
Co phrase search for related documents, hyperlinks ordered by date