Author: Oh, Soo-Jin; Choi, Young-Ki; Shin, Ok Sarah
Title: Systems Biology-Based Platforms to Accelerate Research of Emerging Infectious Diseases Document date: 2018_3_1
ID: ta5y54lu_21
Snippet: Vaccines are one of the greatest successes in the history of mankind. However, despite a global effort to develop vaccines against major infectious diseases, the correlates of protection are still poorly defined for many existing vaccines. Moreover, pathogens can evade and suppress immune responses, and human genetic variability can contribute to host susceptibility to infectious diseases or vaccine responsiveness. Although the eradication of sma.....
Document: Vaccines are one of the greatest successes in the history of mankind. However, despite a global effort to develop vaccines against major infectious diseases, the correlates of protection are still poorly defined for many existing vaccines. Moreover, pathogens can evade and suppress immune responses, and human genetic variability can contribute to host susceptibility to infectious diseases or vaccine responsiveness. Although the eradication of smallpox is one of the many successes of global immunization programs, many vaccine challenges remain, especially for the design of effective vaccines for major killers, such as AIDS, dengue fever, and malaria. 69 Furthermore, there is an urgent need to develop vaccines for EIDs, including the diseases mentioned above and neglected diseases, such as those caused by Chikungunya, Hendra, and Nipah viruses.
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