Author: Peña, José; Chen-Harris, Haiyin; Allen, Jonathan E.; Hwang, Mona; Elsheikh, Maher; Mabery, Shalini; Bielefeldt-Ohmann, Helle; Zemla, Adam T.; Bowen, Richard A.; Borucki, Monica K.
Title: Sendai virus intra-host population dynamics and host immunocompetence influence viral virulence during in vivo passage Document date: 2016_4_9
ID: z7f720dj_58
Snippet: Similarly, at nt 8,073 a G to A substitution resulting in a nonsynonymous change, E461K, occurred between 3 and 22% in the P1 population across all ND and FD samples compared with 8.5% in the seed inoculum. By P10 all mouse samples had the change at detected 16-41%, and the mutation was detected at 26-91% in the guinea pig samples (consensus change for ND.GP3 and SD.GP3)......
Document: Similarly, at nt 8,073 a G to A substitution resulting in a nonsynonymous change, E461K, occurred between 3 and 22% in the P1 population across all ND and FD samples compared with 8.5% in the seed inoculum. By P10 all mouse samples had the change at detected 16-41%, and the mutation was detected at 26-91% in the guinea pig samples (consensus change for ND.GP3 and SD.GP3).
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