Author: Rappuoli, Rino; Bottomley, Matthew J.; D’Oro, Ugo; Finco, Oretta; De Gregorio, Ennio
Title: Reverse vaccinology 2.0: Human immunology instructs vaccine antigen design Document date: 2016_4_4
ID: uyoerxvu_31
Snippet: The data generated so far did not demonstrate that it is possible to generate HIV broadly cross-neutralizing Abs using only germline targeting antigens. However, they suggest that a germline targeting antigen should be used to prime naive B cells encoding the germline precursors of HIV bNAbs, and then native-like HIV Env antigens are required to select and expand B cells expressing cross-neutralizing Abs as a consequence of the somatic hypermutat.....
Document: The data generated so far did not demonstrate that it is possible to generate HIV broadly cross-neutralizing Abs using only germline targeting antigens. However, they suggest that a germline targeting antigen should be used to prime naive B cells encoding the germline precursors of HIV bNAbs, and then native-like HIV Env antigens are required to select and expand B cells expressing cross-neutralizing Abs as a consequence of the somatic hypermutation process. Additional work using multiple intermediate Env antigens is required to obtain a definitive proof of concept for the feasibility of the germline-targeting vaccination approach.
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