Selected article for: "complex protein and protein protein binding"

Author: Amanda D. Melin; Mareike C. Janiak; Frank Marrone; Paramjit S. Arora; James P. Higham
Title: Comparative ACE2 variation and primate COVID-19 risk
  • Document date: 2020_4_11
  • ID: bieqw3x1_10
    Snippet: Critical ACE2 protein contact sites for the viral spike protein receptor binding domain (RBD) have been identified using cryo EM and X-ray crystallography structural analysis methods [14] [15] [16] [17] . The ACE2-RBD complex is characteristic of protein-protein interactions (PPIs) that feature extended interfaces spanning a multitude of binding residues. Experimental and computational analyses of PPIs have shown that a handful of contact residue.....
    Document: Critical ACE2 protein contact sites for the viral spike protein receptor binding domain (RBD) have been identified using cryo EM and X-ray crystallography structural analysis methods [14] [15] [16] [17] . The ACE2-RBD complex is characteristic of protein-protein interactions (PPIs) that feature extended interfaces spanning a multitude of binding residues. Experimental and computational analyses of PPIs have shown that a handful of contact residues can dominate the binding energy landscape 28 .

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