Author: Amanda D. Melin; Mareike C. Janiak; Frank Marrone; Paramjit S. Arora; James P. Higham
Title: Comparative ACE2 variation and primate COVID-19 risk Document date: 2020_4_11
ID: bieqw3x1_11
Snippet: Alanine scanning mutagenesis provides an assessment of the contribution of each residue to complex formation [29] [30] [31] . Critical binding residues can be computationally identified by assessing the change in binding free energy of complex formation upon mutation of the particular residue to alanine, which is the smallest residue that may be incorporated without significantly impacting the protein backbone conformation 32 ......
Document: Alanine scanning mutagenesis provides an assessment of the contribution of each residue to complex formation [29] [30] [31] . Critical binding residues can be computationally identified by assessing the change in binding free energy of complex formation upon mutation of the particular residue to alanine, which is the smallest residue that may be incorporated without significantly impacting the protein backbone conformation 32 .
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