Author: Wang, Yi; Liu, Li
Title: The Membrane Protein of Severe Acute Respiratory Syndrome Coronavirus Functions as a Novel Cytosolic Pathogen-Associated Molecular Pattern To Promote Beta Interferon Induction via a Toll-Like-Receptor-Related TRAF3-Independent Mechanism Document date: 2016_2_9
ID: uf96jgig_3
Snippet: It has been demonstrated in some cases that viral proteins may function as extracellular PAMPs to activate the IFN-I immune response, most often through TLR (such as TLR2 and TLR4) signaling pathways (23) (24) (25) . However, evidence is lacking in regard to whether or not a virus-derived protein can function as a cytosolic PAMP......
Document: It has been demonstrated in some cases that viral proteins may function as extracellular PAMPs to activate the IFN-I immune response, most often through TLR (such as TLR2 and TLR4) signaling pathways (23) (24) (25) . However, evidence is lacking in regard to whether or not a virus-derived protein can function as a cytosolic PAMP.
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