Selected article for: "extended duplex and loop loop kissing"

Author: Ishimaru, Daniella; Plant, Ewan P.; Sims, Amy C.; Yount, Boyd L.; Roth, Braden M.; Eldho, Nadukkudy V.; Pérez-Alvarado, Gabriela C.; Armbruster, David W.; Baric, Ralph S.; Dinman, Jonathan D.; Taylor, Deborah R.; Hennig, Mirko
Title: RNA dimerization plays a role in ribosomal frameshifting of the SARS coronavirus
  • Document date: 2012_12_26
  • ID: zrbn637z_39
    Snippet: To further demonstrate that S3L2 dimerizes via L2-mediated loop-loop kissing interactions, UV-crosslinked dimers were subjected to partial hydrolysis. Normalized densitometry of bands in each lane revealed a significant reduction in 32 P-signal beginning at nucleotide 45 ( Figure 6B ), indicating that this nucleotide is in close proximity to the dimerization interface. The nucleotide at position 45 represents the adenosine 5 0 -neighbor of the 6-.....
    Document: To further demonstrate that S3L2 dimerizes via L2-mediated loop-loop kissing interactions, UV-crosslinked dimers were subjected to partial hydrolysis. Normalized densitometry of bands in each lane revealed a significant reduction in 32 P-signal beginning at nucleotide 45 ( Figure 6B ), indicating that this nucleotide is in close proximity to the dimerization interface. The nucleotide at position 45 represents the adenosine 5 0 -neighbor of the 6-nt palindrome, consistent with SARS S3L2 loop-loop kissing formation ( Figure 5B ) and cannot be explained on the basis of extended duplex formation ( Figure 5C ).

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