Author: Michael Jay Corley; Christopher Sugai; Michael Schotsaert; Robert E. Schwartz; Lishomwa C Ndhlovu
Title: Comparative in vitro transcriptomic analyses of COVID-19 candidate therapy hydroxychloroquine suggest limited immunomodulatory evidence of SARS-CoV-2 host response genes. Document date: 2020_4_14
ID: 30x26ip7_18
Snippet: Previous research in SARS suggested that SARS-CoV regulates immune function-related gene expression in myeloid cells [27] and a report in a SARS-CoV-infected mouse model showed that dysregulated inflammatory and interferon responses of monocyte/macrophage cells caused lethal pneumonia [28] . Clinical data about COVID-19 suggest that peripheral innate immune monocyte cells and lung tissues macrophage cells are critically involved in host response .....
Document: Previous research in SARS suggested that SARS-CoV regulates immune function-related gene expression in myeloid cells [27] and a report in a SARS-CoV-infected mouse model showed that dysregulated inflammatory and interferon responses of monocyte/macrophage cells caused lethal pneumonia [28] . Clinical data about COVID-19 suggest that peripheral innate immune monocyte cells and lung tissues macrophage cells are critically involved in host response and severe disease course [29] . Together, these findings suggest that modulation of myeloid cells may have an impact on SARS-CoV-2-related host responses. Interestingly, research on HCQ suggest that it may impact TLR signaling, antigen presentation, and alter macrophage function [30] . HCQ is also proposed to indirectly have anti-inflammatory effects upon the immune system.
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