Selected article for: "antigen presentation and host response"
Author: Michael Jay Corley; Christopher Sugai; Michael Schotsaert; Robert E. Schwartz; Lishomwa C Ndhlovu
Title: Comparative in vitro transcriptomic analyses of COVID-19 candidate therapy hydroxychloroquine suggest limited immunomodulatory evidence of SARS-CoV-2 host response genes.
  • Document date: 2020_4_14
    • ID: 30x26ip7_18
    Snippet: Previous research in SARS suggested that SARS-CoV regulates immune function-related gene expression in myeloid cells [27] and a report in a SARS-CoV-infected mouse model showed that dysregulated inflammatory and interferon responses of monocyte/macrophage cells caused lethal pneumonia [28] . Clinical data about COVID-19 suggest that peripheral innate immune monocyte cells and lung tissues macrophage cells are critically involved in host response .....
    Document: Previous research in SARS suggested that SARS-CoV regulates immune function-related gene expression in myeloid cells [27] and a report in a SARS-CoV-infected mouse model showed that dysregulated inflammatory and interferon responses of monocyte/macrophage cells caused lethal pneumonia [28] . Clinical data about COVID-19 suggest that peripheral innate immune monocyte cells and lung tissues macrophage cells are critically involved in host response and severe disease course [29] . Together, these findings suggest that modulation of myeloid cells may have an impact on SARS-CoV-2-related host responses. Interestingly, research on HCQ suggest that it may impact TLR signaling, antigen presentation, and alter macrophage function [30] . HCQ is also proposed to indirectly have anti-inflammatory effects upon the immune system.

    Search related documents:
    Co phrase search for related documents
    • anti inflammatory effect and gene expression: 1, 2, 3, 4, 5
    • anti inflammatory effect and host response: 1, 2, 3, 4, 5, 6, 7
    • anti inflammatory effect and immune system: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14
    • anti inflammatory effect and immune system anti inflammatory effect: 1, 2, 3
    • anti inflammatory effect and lung tissue: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
    • anti inflammatory effect and macrophage cell: 1, 2
    • antigen presentation and disease course: 1, 2, 3, 4, 5, 6, 7, 8
    • antigen presentation and gene expression: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • antigen presentation and host response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • antigen presentation and immune monocyte: 1
    • antigen presentation and immune system: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • antigen presentation and lung tissue: 1, 2, 3, 4, 5, 6, 7, 8, 9
    • antigen presentation and macrophage cell: 1, 2, 3, 4
    • antigen presentation and macrophage function: 1, 2
    • cov infect and gene expression: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • cov infect and host response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15
    • cov infect and immune system: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16
    • cov infect and lethal pneumonia: 1
    • cov infect and lung tissue: 1, 2, 3, 4, 5, 6, 7