Selected article for: "bronchoalveolar lavage and lung tissue"
Author: Michael Jay Corley; Christopher Sugai; Michael Schotsaert; Robert E. Schwartz; Lishomwa C Ndhlovu
Title: Comparative in vitro transcriptomic analyses of COVID-19 candidate therapy hydroxychloroquine suggest limited immunomodulatory evidence of SARS-CoV-2 host response genes.
  • Document date: 2020_4_14
    • ID: 30x26ip7_3
    Snippet: While the efficacy of HCQ as a treatment for COVID-19 remains to be determined, we hypothesized that comparative analyses of HCQ transcriptome signatures and SARS-CoV-2-related host transcriptional responses may provide insight into mechanisms of HCQ treatment. To start to test this hypothesis, we investigated transcriptional signatures of HCQ treated human primary PBMC, human monocyte-derived macrophages, and human plasmacytoid dendritic cells i.....
    Document: While the efficacy of HCQ as a treatment for COVID-19 remains to be determined, we hypothesized that comparative analyses of HCQ transcriptome signatures and SARS-CoV-2-related host transcriptional responses may provide insight into mechanisms of HCQ treatment. To start to test this hypothesis, we investigated transcriptional signatures of HCQ treated human primary PBMC, human monocyte-derived macrophages, and human plasmacytoid dendritic cells in relation to in vitro SARS-CoV-2 infection and COVID-19 participant PBMC, bronchoalveolar lavage, and postmortem lung tissue biopsy transcriptional signatures. These comparative transcriptome findings do not address the question of the efficacy of HCQ in patients with COVID-19, but begin to explore potential mechanisms of HCQ in the setting of SARS-CoV-2 infection.

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