Author: Grove, Joe; Marsh, Mark
Title: The cell biology of receptor-mediated virus entry Document date: 2011_12_26
ID: v4op73hf_36
Snippet: Several viruses exploit motor proteins to travel along the cytoskeleton within the cell body (Greber and Way, 2006) . HIV, Herpes simplex virus, and adenovirus all appear to exploit dynein-mediated retrograde microtubule translocation to facilitate transport to the nucleus and infection (Sodeik et al., 1997; Suomalainen et al., 1999; McDonald et al., 2002) . The use of (Alvarez et al., 2002; Simmons et al., 2003) , facilitating interaction with t.....
Document: Several viruses exploit motor proteins to travel along the cytoskeleton within the cell body (Greber and Way, 2006) . HIV, Herpes simplex virus, and adenovirus all appear to exploit dynein-mediated retrograde microtubule translocation to facilitate transport to the nucleus and infection (Sodeik et al., 1997; Suomalainen et al., 1999; McDonald et al., 2002) . The use of (Alvarez et al., 2002; Simmons et al., 2003) , facilitating interaction with the receptor TIM-1. (B) Axl receptor tyrosine kinase is thought to promote virus particle uptake via macropinocytosis. Critically, Ebola virus does not directly engage Axl; the Axl ligand Gas-6 may associate with virus particles and facilitate indirect interaction between Ebola virus and Axl, as demonstrated for other viruses (Morizono et al., 2011) . (C) Within the late endosome/lysosome, viral glycoprotein GP1 undergoes sequential proteolytic cleavage by cathepsins L and B, allowing interaction with NPC1, a putative endosomal receptor. Ebola virus membrane fusion is dependent on the viral glycoprotein GP2 and occurs from the late endosome/lysosome, although the exact molecular triggers remain unclear.
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