Author: Hao, Xin-yan; Lv, Qi; Li, Feng-di; Xu, Yan-feng; Gao, Hong
Title: The characteristics of hDPP4 transgenic mice subjected to aerosol MERS coronavirus infection via an animal nose-only exposure device Document date: 2019_10_30
ID: vkjcheaz_3
Snippet: Nonhuman primate animal models of MERS-CoV in both rhesus macaques and common marmosets were established in previous reports, 6, 7 however, these models are limited by restricted availability, high costs, expert husbandry requirements, and ethical concerns. 8, 9 Traditional small animals such as mice, hamsters, and ferrets cannot be infected with MERS-CoV owing to absence of the necessary dipeptidyl peptidase 4 (DPP4) receptor that interacts with.....
Document: Nonhuman primate animal models of MERS-CoV in both rhesus macaques and common marmosets were established in previous reports, 6, 7 however, these models are limited by restricted availability, high costs, expert husbandry requirements, and ethical concerns. 8, 9 Traditional small animals such as mice, hamsters, and ferrets cannot be infected with MERS-CoV owing to absence of the necessary dipeptidyl peptidase 4 (DPP4) receptor that interacts with the receptor binding domain of the MERS-CoV spike protein (S protein) [10] [11] [12] MERS-CoV fails to replicate in mice, which are readily available, have a defined genetic background and low cost and are frequently used in infectious disease research, due to variations in the DPP4 receptor. Previous studies showed that transgenic mice expressing the human DPP4 (hDPP4) receptor could be infected intranasally with MERS-CoV and developed acute pneumonia. [13] [14] [15] Therefore, hDPP4 transgenic mice were selected for exposure to MERS-CoV-containing aerosols using an animal nose-only exposure device.
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