Author: Teoh, Kim-Tat; Siu, Yu-Lam; Chan, Wing-Lim; Schlüter, Marc A.; Liu, Chia-Jen; Peiris, J. S. Malik; Bruzzone, Roberto; Margolis, Benjamin; Nal, Béatrice
Title: The SARS Coronavirus E Protein Interacts with PALS1 and Alters Tight Junction Formation and Epithelial Morphogenesis Document date: 2010_11_15
ID: ufw13pjx_72
Snippet: Lastly, analysis of MDCKII eGFP-PALS1, HA-E (ΔPBM) cells indicated that these cells did not present a notable polarity defect at 2 h post-calcium switch (Figure 7C). In these cells, both eGFP-PALS1 and ZO-1 were found at the TJ, whereas GP135 was enriched at the apical surfaces. HA-E (ΔPBM) was diffusely distributed in the cell cytoplasm, indicating a role of the DLLV motif in E accumulation in the perinuclear compartment. This result also demo.....
Document: Lastly, analysis of MDCKII eGFP-PALS1, HA-E (ΔPBM) cells indicated that these cells did not present a notable polarity defect at 2 h post-calcium switch (Figure 7C). In these cells, both eGFP-PALS1 and ZO-1 were found at the TJ, whereas GP135 was enriched at the apical surfaces. HA-E (ΔPBM) was diffusely distributed in the cell cytoplasm, indicating a role of the DLLV motif in E accumulation in the perinuclear compartment. This result also demonstrates that the DLLV motif of E plays a major role in alteration of polarity in monolayers of MDCKII cells.
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