Selected article for: "cell type and virus cell type"

Author: Teoh, Kim-Tat; Siu, Yu-Lam; Chan, Wing-Lim; Schlüter, Marc A.; Liu, Chia-Jen; Peiris, J. S. Malik; Bruzzone, Roberto; Margolis, Benjamin; Nal, Béatrice
Title: The SARS Coronavirus E Protein Interacts with PALS1 and Alters Tight Junction Formation and Epithelial Morphogenesis
  • Document date: 2010_11_15
  • ID: ufw13pjx_82
    Snippet: In a recent large-scale genome-wide screen, Obenauer and coworkers have discovered the presence of a PBM at the CT of NS1 protein of the H5N1 avian influenza A virus (Obenauer et al., 2006). Presence of this PBM was shown to be detrimental virulence factor in mice (Jackson et al., 2008). Interestingly, similar PBM have been characterized and identified at the CT of several viral oncoproteins, namely adenovirus type 9 E4-ORF1, human T-cell leukemi.....
    Document: In a recent large-scale genome-wide screen, Obenauer and coworkers have discovered the presence of a PBM at the CT of NS1 protein of the H5N1 avian influenza A virus (Obenauer et al., 2006). Presence of this PBM was shown to be detrimental virulence factor in mice (Jackson et al., 2008). Interestingly, similar PBM have been characterized and identified at the CT of several viral oncoproteins, namely adenovirus type 9 E4-ORF1, human T-cell leukemia virus type 1 Tax1, and human papillomavirus E6. These viral PBM bind to PDZ domain-containing proteins involved in the regulation of epithelial cell polarity and induced epithelial-to-mesenchyme transformation in a PBM–dependent manner (reviewed in Javier, 2008; Liu and Baleja, 2008; Thomas et al., 2008; Tungteakkhun et al., 2008; Wise-Draper and Wells, 2008; Tomaic et al., 2009). Likewise, SARS-CoV may interfere with epithelial apicobasal polarity through molecular interactions involving the E CT domain.

    Search related documents:
    Co phrase search for related documents
    • genome wide screen and NS1 protein: 1
    • human papillomavirus and large scale: 1, 2, 3, 4
    • human papillomavirus and leukemia virus: 1, 2
    • human papillomavirus and NS1 protein: 1, 2
    • human papillomavirus and pbm bind: 1
    • human papillomavirus and viral oncoprotein: 1
    • large scale and leukemia virus: 1, 2, 3, 4, 5
    • large scale and molecular interaction: 1, 2, 3, 4
    • large scale and NS1 protein: 1
    • molecular interaction and virulence factor: 1, 2