Selected article for: "genome replication and RNA dependent RNA polymerase"
Author: te Velthuis, Aartjan J.W.; van den Worm, Sjoerd H. E.; Snijder, Eric J.
Title: The SARS-coronavirus nsp7+nsp8 complex is a unique multimeric RNA polymerase capable of both de novo initiation and primer extension
  • Document date: 2011_10_29
    • ID: tx0lqgff_1
    Snippet: In the replicative cycle of RNA viruses, the crucially important process of RNA-templated RNA synthesis is generally performed by an RNA-synthesizing complex of viral enzymes (1, 2) . Commonly, its core subunit is a single RNA-dependent RNA polymerase (RdRp) that drives the production of template strands for replication, new genome molecules, and-in many RNA virus groupsalso subgenomic (sg) mRNAs. This canonical RdRp is structurally conserved amo.....
    Document: In the replicative cycle of RNA viruses, the crucially important process of RNA-templated RNA synthesis is generally performed by an RNA-synthesizing complex of viral enzymes (1, 2) . Commonly, its core subunit is a single RNA-dependent RNA polymerase (RdRp) that drives the production of template strands for replication, new genome molecules, and-in many RNA virus groupsalso subgenomic (sg) mRNAs. This canonical RdRp is structurally conserved among RNA viruses and widely accepted to drive catalysis of phosphodiester bond formation via a well-established reaction mechanism involving two metal ions that are coordinated by aspartate residues in its motifs A and C (3) (4) (5) .

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