Author: Peña, José; Chen-Harris, Haiyin; Allen, Jonathan E.; Hwang, Mona; Elsheikh, Maher; Mabery, Shalini; Bielefeldt-Ohmann, Helle; Zemla, Adam T.; Bowen, Richard A.; Borucki, Monica K.
Title: Sendai virus intra-host population dynamics and host immunocompetence influence viral virulence during in vivo passage Document date: 2016_4_9
ID: z7f720dj_74
Snippet: Similar to our data, a mutation at HN residue 525 (Q525R) was reported by Itoh et al. (1992) . The R525 mutation appeared after passage in eggs and was associated with conformational changes in the receptor binding site and increased neuraminidase activity, but was not associated with mouse pathogenicity (Itoh et al. 1992) . In this study, the egg-passaged seed stock had a positively charged residue, Lys, as consensus with a Gln present as a vari.....
Document: Similar to our data, a mutation at HN residue 525 (Q525R) was reported by Itoh et al. (1992) . The R525 mutation appeared after passage in eggs and was associated with conformational changes in the receptor binding site and increased neuraminidase activity, but was not associated with mouse pathogenicity (Itoh et al. 1992) . In this study, the egg-passaged seed stock had a positively charged residue, Lys, as consensus with a Gln present as a variant. This mutation, K525Q, was detected with increasing frequency in P10 and guinea pig passages as compared with the seed and P1 samples. Genotype Q525 became the consensus sequence by guinea pig passage in two of the three guinea pigs from the FD and SD groups.
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