Author: Angelini, Megan M.; Akhlaghpour, Marzieh; Neuman, Benjamin W.; Buchmeier, Michael J.
Title: Severe Acute Respiratory Syndrome Coronavirus Nonstructural Proteins 3, 4, and 6 Induce Double-Membrane Vesicles Document date: 2013_8_13
ID: yl1qyh7j_2
Snippet: Coronaviruses, members of the Nidovirales order, are enveloped, positive-sense, single-stranded RNA viruses (12) (13) (14) . Their genome is the largest of all known RNA viruses, ranging from approximately 26 to 32 kb. The SARS coronavirus genome is 29.7 kb in size, the first two-thirds of which encompasses the over-lapping open reading frames 1a and 1b (ORF1a/b) (15, 16) . ORF1a/b is translated into two large polyproteins (pp): pp1a and, via a f.....
Document: Coronaviruses, members of the Nidovirales order, are enveloped, positive-sense, single-stranded RNA viruses (12) (13) (14) . Their genome is the largest of all known RNA viruses, ranging from approximately 26 to 32 kb. The SARS coronavirus genome is 29.7 kb in size, the first two-thirds of which encompasses the over-lapping open reading frames 1a and 1b (ORF1a/b) (15, 16) . ORF1a/b is translated into two large polyproteins (pp): pp1a and, via a frameshift event, pp1ab (17) (18) (19) . These polyproteins are coand posttranslationally cleaved by viral proteases into the 16 nonstructural proteins (nsps) involved in viral genome replication and transcription (20, 21) .
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