Author: Nicholls, John M
Title: The Battle Between Influenza and the Innate Immune Response in the Human Respiratory Tract Document date: 2013_3_29
ID: vyci1ho3_39
Snippet: The TRIM proteins are called such because they have a TRIpartite Motif and even though there have been over 70 genes encoding TRIM described, only a small number have been well characterized [61] . Since it was demonstrated that genes encoding TRIM were upregulated by type-1 interferons their role has been further investigated [66] . As mentioned above TRIM25 ubiquitinates and activates RIG-1, TRIM30α inhibits NF1κβ, TRIM21 stabilizes IRF3 and.....
Document: The TRIM proteins are called such because they have a TRIpartite Motif and even though there have been over 70 genes encoding TRIM described, only a small number have been well characterized [61] . Since it was demonstrated that genes encoding TRIM were upregulated by type-1 interferons their role has been further investigated [66] . As mentioned above TRIM25 ubiquitinates and activates RIG-1, TRIM30α inhibits NF1κβ, TRIM21 stabilizes IRF3 and TRIM27 inhibits NF1κβ, IRF3 and IRF7, thus affecting the downstream activation pathway in viral infection. Once CARDs are expressed and ubiquitnated they are able to interact with the CARDs of the adaptor protein Mitochondrial AntiViral Signaling (MAVS) on mitochondria leading to activation of the IKKα-IKKß-IKKγ complex and the downstream NFκß, IRF3 and IRF7 complexes followed by transcription of type 1 interferons.
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