Author: Raison, C L; Miller, A H
Title: The evolutionary significance of depression in Pathogen Host Defense (PATHOS-D) Document date: 2012_1_31
ID: twgs7akl_3
Snippet: To fully elaborate this hypothesis, this article is structured to evaluate the foundations of the PATHOS-D theory (Table 1 ) by first examining the immune relevance of previously identified depression risk alleles, followed by an exploration of relationships among environmental risk factors for depression, inflammation and pathogen host defense. The role of depression-associated immune changes in promoting survival during infection is reviewed ne.....
Document: To fully elaborate this hypothesis, this article is structured to evaluate the foundations of the PATHOS-D theory (Table 1 ) by first examining the immune relevance of previously identified depression risk alleles, followed by an exploration of relationships among environmental risk factors for depression, inflammation and pathogen host defense. The role of depression-associated immune changes in promoting survival during infection is reviewed next, followed by an examination of the potential utility of depressive symptoms in host defense. We conclude with a consideration of the potential limitations of-and challenges to-the PATHOS-D theory.
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