Selected article for: "negative sense and RNA polymerase"
Author: Liu, Yuan-yuan; Chen, Liang-jun; Zhong, Yan; Shen, Meng-xin; Ma, Nian; Liu, Bing-yu; Luo, Fan; Hou, Wei; Yang, Zhan-qiu; Xiong, Hai-rong
Title: Specific interference shRNA-expressing plasmids inhibit Hantaan virus infection in vitro and in vivo
  • Document date: 2016_3_14
    • ID: pwlybr2h_1
    Snippet: Hantaviruses represent one of the important emerging and re-emerging viral groups and have become a global threat to public health in different areas of the world [1, 2] . Hantaviruses lead to two severe febrile diseases worldwide, ie, hemorrhagic fever with renal syndrome (HFRS) in Eurasia due to Old World hantavirus and hantavirus pulmonary syndrome (HPS) in the Americas due to New World hantavirus [3] . Approximately 60 000-100 000 HFRS cases .....
    Document: Hantaviruses represent one of the important emerging and re-emerging viral groups and have become a global threat to public health in different areas of the world [1, 2] . Hantaviruses lead to two severe febrile diseases worldwide, ie, hemorrhagic fever with renal syndrome (HFRS) in Eurasia due to Old World hantavirus and hantavirus pulmonary syndrome (HPS) in the Americas due to New World hantavirus [3] . Approximately 60 000-100 000 HFRS cases are reported each year worldwide, and the mortality rate can reach 10% [1, 4] . Hantaviruses belong to the genus Hantavirus of the Bunyaviridae family, and they are enveloped, single-strand, negative-sense, tri-segmented RNA viruses. The viral genomes consist of large (L), medium (M) and small (S) segments that encode an RNA-dependent RNA polymerase and two envelope glycoproteins (Gn and Gc) and a nucleocapsid (N) protein. Variations in the M and S segments may influence the antigenicity and virulence of hantaviruses [5, 6] .

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