Selected article for: "activity domain and functional domain"
Author: Klaile, Esther; Vorontsova, Olga; Sigmundsson, Kristmundur; Müller, Mario M.; Singer, Bernhard B.; Öfverstedt, Lars-Göran; Svensson, Stina; Skoglund, Ulf; Öbrink, Björn
Title: The CEACAM1 N-terminal Ig domain mediates cis- and trans-binding and is essential for allosteric rearrangements of CEACAM1 microclusters
  • Document date: 2009_11_16
    • ID: uy2553z7_35
    Snippet: The present data highlight the central role of the N-terminal D1 Ig domain in the functional activity of CEACAM1. A crucial finding was that two different sites in the D1 domain could participate simultaneously in homophilic binding. It is well established that either the CFG or the ABED face can HP; GE Healthcare) and size-exclusion chromatography (Superdex 200; GE Healthcare). Protein purity was determined by SDS-PAGE and Coomassie staining (Fi.....
    Document: The present data highlight the central role of the N-terminal D1 Ig domain in the functional activity of CEACAM1. A crucial finding was that two different sites in the D1 domain could participate simultaneously in homophilic binding. It is well established that either the CFG or the ABED face can HP; GE Healthcare) and size-exclusion chromatography (Superdex 200; GE Healthcare). Protein purity was determined by SDS-PAGE and Coomassie staining (Fig. S2) .

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